To extract unique sequences from a group of sequences:

• Read into ICM the sequences you wish to make unique.
• Select the sequences. A sequence can be selected by double clicking (highlighted blue in ICM workspace) - a range of sequences in the ICM Worskpace can be selected by holding down the SHIFT button and double clicking. A non-contiguous selection can be made by holding down the CTRL button and double clicking.
• Right click on the sequence selection in the ICM Workspace and select Group sequences
• Bioinfo/Extract Unique Sequences
• Enter the name of the sequence group.
• Enter the number of residue mismatches necesary to determine that a sequence is unique or not.
• Select whether you want to keep the redundant sequences or delete them from ICM.