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Background ICM provides a powerful graphical interface for cheminformatics. The cheminformatics tools are fast and easy to use and facilitate manipulation of chemical compound data in a number of unique and effortless ways. You can load and display chemical structures in chemical tables or build your own chemical structures using the ICM Molecular Editor. Within the table any amount information can be stored, searched, analyzed and plotted. Chemical databases can be created in a matter of seconds for use in virtual screening or for further analysis. Once a chemical database is loaded into ICM it can be searched using state-of-the-art chemical similarity tools and substructure searching. Also, the chemical compounds can be clustered according to chemical similarity allowing for more targeted screening. New features such as the ICM drug-likeness analysis software facilitate cost-efficient and accurate drug discovery and chemical structure analysis.