A chemical table or an .sdf file can be converted to 3D and sampled using the conformational generator with the _confGen script provided with the ICM distribution.

_confGen [-f] [-I] [-s] input.sdf output.sdf .. [thoroughness=1.] [mnconf=50] [vicinity=30]

• thoroughness : the relative mc sampling effort. Increase for more rigorous sampling
• mnconf : the maximal number of conformers per compound
• vicinity : the root-mean-square deviation threshold for the rotatable torsions
• auto= max : number of rotatable bonds to auto switch between systematic and MC
• -q : quiet (suppress warnings)
• -f : force overwriting of the output file
• -s : use systematic search instead of MC
• -r : sample flexible ring systems
• -d : sample cis/trans for double bonds
• -c : improve geometries and energies with cartesian MMFF minimization
• -hydrogen : keep hydrogens in the result table
• -molcart= connect_string : host,user,pass,database