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MolSoft Releases Major New ICM Version (v.3.7-2)

MolSoft is excited to announce the release of ICM v3.7-2 which is a major new version upgrade with many new features and an updated user interface. You can download the latest version at our support site. Below is a summary of the new features along with some screenshots. Click here to jump to new feature descriptions.


Screenshots of New Features in Version 3.7-2 - Click to enlarge

Improved Alignment Annotation

One click display of UniProt (and user defined) annotation on sequence alignments.


The new HTML WYSIWYG editor provides an interface which resembles how the page will be displayed in a web browser - no knowledge of HTML is required!

Drag & Drop Copy & Paste

Copy and Paste and Drag and Drop Between Different ICM Sessions.

Receptor Refinement

A new option is available in the ligand editor to incorporate receptor side-chain refinement once a chemical modification is made.

CPK Clip Capping

A new preference to control the way CPK spheres are displayed when cut by a clipping plane.

Direct links to PDB and UniProt Websites

New icons and new ways of including external and internal links into ICM tables.

New ICM Force Field

Arnautova et al Proteins 2010

Explicit Group Docking

This new feature allows you to define flexible receptor residues during docking or virtual screening.

New ICM Force Field

The new force-field contains new parametization for the dielectric constant, an improved hydrogen bond determination method, and implementation of novel backbone atom torsional potentials which include bond anlges of the carbon (alpha) atoms into the internal variable set. Please see the publication in the Proteins journal by Arnautova et al where the force-field has been applied to protein loop modeling.

Follow these instructions to use the new force field in your own scripts for energy minimization and optimization. If you are interested in modeling loops you can use the _loopmodel macro where all these parameters are already pre-set.

New HTML Editor for Molecular Documents

WebKit Integration

WebKit has been integrated into the latest ICM version. This will allow:

Graphics and User Interface

Docking and Virtual Ligand Screening


New Features Added to the Free ICM-Browser

Build and save fully-annotated and interactive 3D molecules and display them in Safari, Firefox, Google Chrome, and Internet Explorer.

3D Interactive Ligand Editor

Implicit Membrane Models

Define shapes with lipids or water for implicit solvation calculaions using TOOLS.membrane array. Each atom is considered as either buried by other explicit atoms of the object or exposed. When the surfaceMethod is defined as membrane then each atom can be either in water environment or in lipid environment. The way to define the membrane models is discussed in more detail here.

PDB Search

Sequences and Alignments

Tools Menu

MolMechanics Menu

ICM Shell

Additional new features and improvements can be found in our Release Notes.