Multi Parameter Optimzation (MPO) is a method that can be used to derive a score for the relative importance of a number of different chemical properties. For example Lipinski Rules (LopP, MW, Nof(HBD) , Nof(HBA) and CNS (LogP, PSA, MW, pKa, MW, Nof(HBD).

To run MPO:

• Read in a Chemical table.
• Chemistry/MPO/Create New MPO Score
• Select the inbuilt Lipinski or CNS parameters or make your own by choosing Empty.
• Choose whether you want to assign property colors and click OK.
• You will then see a panel on the right hand side of the spreadsheet under the table Tools tab.
• If you chose "Empty" you will need to add parameters either from MolSoft's inbuilt functions or from an existing column.
• If needed Adjust the High, Low, Slope, Value and Weight columns by clicking in the cell and editing.

• Click on Calculate MPO Score and a results table will be displayed containing a Score and the parameter bars.
• Sort the Score column (myMPO).