Background

ActiveICM (Patent Pending) enables you to view and display 3D ICM graphical slides and animations interactively inside Microsoft PowerPoint and web browsers such as Internet Explorer, Safari and Mozilla Firefox. The files can be prepared and saved in ICM Browser Pro or ICM Pro. Please click here for instructions on how to use ActiveICM.

Click on the image to enlarge. Image Copyright:2009 Raush et al. PLoS ONE 4(10)

Inside a single file you can save and display many different data types such as sequences, alignments, plots, tables, protein and DNA/RNA structures. Each data element can be linked to one another and annotated and then shared via the web, MS Office tools or in the free ICM-Browser. Pharmaceutical and biotech companies use ActiveICM to share data between scientists in different disciplines. Academic laboratories such as the SGC publish their data to the world using ActiveICM in a web browser.

ActiveICM Examples

Below are some fully-interactive documents utilizing ActiveICM showing the targets for some common drug molecules. Click on the image to view ActiveIM in action. NOTE: The demo will only work if you download ActiveICM. Click here to download ActiveICM.

Antibiotic drugs.	Antiviral drugs.
Anticancer drugs.	Heart disease drugs.

Click here to view an example from the SGC. Use your left mouse button to rotate the molecule, zoom in by clicking on the left hand side of the display, scroll down the text on the left hand side and click on the blue links to see different annotated views of the protein, right click on the graphical display for more options.

Download ActiveICM

Documentation

For written documentation please see the ActiveICM User Guide and the ICM-Browser User Guide. Please see the videos below for a guide to generating fully-interactive 3D molecular files in PowerPoing and on the Web.

How to Download and Install ICM-Browser	How to Download and Install AvtiveICM
How to Generate a Series of Fully-Interactive 3D Slides	How to Add Hyperlinked HTML Text to a 3D Document File
How to Embed Fully-Interactive 3D Documents into a PowerPoint File	How to Embed Fully-Interactive 3D Documents into a Web Browser

See ActiveICM in Action

	The electronic journal PLoS ONE has launched a collection of scientific research papers which uses ActiveICM to deliver the paper content in a clear and visual way. See the Press Release about this here on our website.
	The Structural Genomics Consortium (SGC) publish all their data on the web using ActiveICM. The SGC were the first to really take on board the ActiveICM technology and collaborate with MolSoft. Visit their website to see the galleries of crystal structures that they have solved displayed using ActiveICM.

ActiveICM References

1. The first description of the ActiveICM method:

Abagyan et al. Disseminating structural genomics data to the public: from a data dump to an animated story (2006). Trends Biochem Sci. 2006 Feb;31(2):76-8. Epub 2006 Jan 6.

2. The ActiveICM concept applied to publishing:

Lee et al. SGC - Structural Biology and Human Health: A New Approach to Publishing Structural Biology Results (2009). PLoS ONE 4(10): e7675. doi:10.1371/journal.pone.0007675.

3. ActiveICM techology description.

Raush et al. A New Method for Publishing Three-Dimensional Content (2009). PLoS ONE 4(10): e7394. doi:10.1371/journal.pone.0007394.

Release Notes

See release notes for the list of the latest changes.