Mar 8 2010
Contents
 
Introduction
How To?
Menu Options
Graphics Tools
Tabs
Selections
Tables
Local DB
Sequences
Homology and Modelling
Working with Chemistry Tools
Chemsitry Menu
Docking
Ligand Editor
Animations, Slides, & Documents
ActiveICM
Movie Making
Frequently Asked Questions
Tutorials
 
Index
PrevICM User's Guide
1 Introduction
Next

Background

The ICM Suite of Software provides an easy to use general environment for a biologist or chemist who is curious about protein structure. In just a few seconds you can browse hundreds of structures of interest, analyze and visualize sequences, alignments and binding sites. Also you can perform molecular modeling, fully-flexible ligand and receptor docking, virtual ligand screening, chemical similarity searching, chemical clustering and much more... This book describes how to use the program via the Graphical User Interface (GUI) without the knowledge of the commands and functions running through your terminal window. After reading this book you may read the full ICM Language Reference Manual (www.molsoft.com/man) for the dying breed of command line users and occasional programmers. This is a separate document which is provided with a full ICM distribution or can be obtained from Molsoft in a printed form.

ICM is constantly updated with new features and so it is always a good idea to keep an eye on the release notes. Most of the things you will read in this manual are sort of natural or can be figured out by common sense and trial-and-error. However, if you like to read a "structured" description of the material, go ahead and read this.Since this book is intended for basically anyone who is even remotely interested in molecules, some basic knowledge of biology and chemistry is implied. Do not try to find definitions of "atom" or "sequence" here, but most terms beyond that will be explained. A keyword search of this manual is available on the online version which is located at (www.molsoft.com/gui). This book covers the graphical user interface only. For detailed information regarding ICM programming please consult the separate ICM language reference guide (www.molsoft.com/man).If you want to have a more hands-on introduction to ICM you are always more than welcome to join us at one of our ICM workshops which are held periodically throughout the year (click here for training information).

ICM Specifications and Recomendations

Minimum specification for Windows, Mac, SGI and Linux:

55 Mb of disk space and 256Mb or more of memory. 512Mb of memory is good enough. Our databases such as XPDB require another 1Gb of disk space.

The Graphic card should have Hardware OpenGL acceleration and 64Mb or more memory. (128Mb or more is recommended)

We recommend NVIDIA (http://www.nvidia.com) brand.

  • GeForce models are good if you do not plan to use hardware stereo.
  • Quadro models can be used with hardware stereo

If you need Stereo Glasses we can recommend CrystalEyes: http://reald-corporate.com/scientific/crystaleyes.asp

Before you can begin you need to download and install ICM-Browser, ICM-Browser-Pro, or ICM-Pro. See below for instructions on how to do this.

Requesting an ICM license and Installation

To obtain an ICM license (either trial of full) please follow these steps:

You can choose either a nodelocked or floating license. A nodelocked license will be for a single machine whereas a floating license will be placed on a server and can be accessed from any machine connected to that server.

  1. Go to our support page.
  2. Enter your login information or go here to register with us.
  3. Click on downloads
  4. Select which platform
  5. Select ICM (Full Package) - follow the download instructions and remember to generate the hostid (see below).
  6. Click on the hostid link - the first instruction in the installation guide (windows) or follow the instructions on the website (Linux/SGI). If you would like a floating license follow the instructions for floating license and send the IP address or name of the server in addition to the FlexLM id.
  7. Send key to andy@molsoft.com or info@molsoft.com
  8. A license will be sent to you by E mail usually as an attachment. Follow the instructions on www.molsoft.com/support on where to save the license.


Prev
Home
Up
Next
How To?

Copyright© 1989-2008, Molsoft,LLC - All Rights Reserved.
This document contains proprietary and confidential information of Molsoft, LLC.
The content of this document may not be disclosed to third parties, copied or duplicated in any form,
in whole or in part, without the prior written permission from Molsoft, LLC.