To run RIDGE:

• Setup a docking project.
• Go to Docking/Run RIDGE HTD VLS
• Select the conformer database in .molt format you wish to screen. You can download pre-prepared databases here. or prepare your own molt database using the options in Chemistry/Generate Conformers.
• Select a RTCNN score cutoff - it is reccommended to undertake a test screen to see what score distributions you will obtain for your receptor.
• Clash weight penalty - recommended to use the default value of 20.
• You can choose to also evaluate the physics-based score.

There are some Advanced options:

• Clash van der Waals scale (default = 0.82)
• Select a random subset to screen and enter the size of the subset.
• Define the GPU ID number.