There are a number of different ways to load a sequence into ICM via the Graphical User Interface.

Read a Sequence from SwissProt

Swissprot is a curated protein sequence database which provides a high level of annotation (such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc.). Each protein entry has an unique SwissID code associated. To retrieve a Swissprot annotated protein sequence enter the SwissID code and click 'OK'. The annotation can be transferred to a protein structure, providing that the structure has the same sequence (or has been aligned to the retrieved Swissprot sequence)

• File/Load/SWISSPROT
• Enter SWISSPROT ID

Paste your own sequence into ICM

• File/New/Sequence
• Paste the Sequence into the box provided.

Extract a Sequence from a PDB file

• Right click on a loaded PDB file in the ICM Workspace.
• Select Extract Sequence(s)

Read from file

If you have a sequence file saved in FASTA format it can be read into ICM by:

• File/Open