ICM User's Guide: PROTAC Modeling

Apr 15 2026 Feedback.

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Contents


Introduction
Help Videos
Reference Guide
Getting Started
Protein Structure
Molecular Graphics
Slides & ActiveICM
Sequences & Alignments
Protein Modeling
Cheminformatics
Learn and Predict
Docking
Virtual Screening
Molecular Dynamics
MolScreen
3D Ligand Editor
Tables and Plots
Local Databases
ICM-Scarab
KNIME
Tutorials
Workshop Examples
Introduction to ICM
Drug Target Analysis and Preparation
Protein Modeling and Engineering
Chemical Structure Analysis SAR and Library Design
Ligand Editor
Ligand Docking
Virtual Screening
PROTAC Modeling
MolScreen
Molecular Dynamics
GPU/AI 3D- Structure and Ligand Based Library Screening of Ultra Large Libraries
FAQs

Index

ICM User's Guide
22.8 PROTAC Modeling

PROTAC and molecular glue design in ICM enables structure-based modeling of ternary complexes that drive targeted protein degradation. These approaches focus on bringing a target protein into proximity with an E3 ubiquitin ligase, forming a productive complex that leads to ubiquitination and degradation. By combining docking, conformational sampling, and scoring within a unified framework, ICM supports the exploration and optimization of degrader molecules, including linker geometry, binding cooperativity, and overall complex stability.

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