[ UniProt | Cut and Paste | Extract from PDB | From File | Save Sequence ]

There are a number of different ways to load a sequence into ICM via the Graphical User Interface.

Uniprot is a curated protein sequence database which provides a high level of annotation (such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc.).

To read a sequence from UniProt:

• File/Load/UniProt
• Enter UniProt ID

or use the option in the Search Tab.

Paste your own sequence into ICM

• File/New/Sequence
• Paste the Sequence into the box provided.

Extract a Sequence from a PDB file

• Right click on a molecule in a loaded PDB file in the ICM Workspace.
• Select Extract Sequence(s) and the sequence will be loaded into the Sequences section of the ICM Workspace.

To read a sequence from a file:

If you have a sequence file saved in FASTA format it can be read into ICM by:

• File/Open

To save a sequence in FASTA format:

• Right click on the sequence name in the ICM workspace.
• Select the option Save As.
• Choose FASTA format from the Windows "Save as type:" drop down menu option.