How to Mutate or Modify an Amino Acid Residue

In order to make a mutation the molecule needs to be an ICM Object. Right click on the amino acid residue you wish to mutate and choose Advanced and then select one of the mutation options. For the extended list of unusual amino acids the codes in the drop down box refer to the codes at the PDB Ligand Expo website here http://ligand-expo.rcsb.org/